Cymbalta (Duloxetine Hcl): Side Effects, Interactions ...
Cymbalta (Duloxetine Hcl): Side Effects, Interactions ...
Learn about Cymbalta (Duloxetine Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.

Safety of doses above 120 mg once daily has not been adequately evaluated [see Initiate CYMBALTA at a dose of 30 mg once daily for 2 weeks before considering an increase to 60 mg. Nevertheless, if a decision is made to increase the dose beyond 60 mg once daily, increase dose in increments of 30 mg once daily. I took a low dose and it still worked. Because it is possible that CYMBALTA and alcohol may interact to cause liver injury or that CYMBALTA may aggravate pre-existing liver disease, CYMBALTA should not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease. Common adverse reactions reported as a reason for discontinuation and considered to be drug-related (as defined above) included nausea (CYMBALTA 3.

Do not take two doses of CYMBALTA at the same time. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Patients should be monitored for the emergence of serotonin syndrome. Case reports and epidemiological studies (case-control and cohort design) have demonstrated an association between use of drugs that interfere with serotonin and the occurrence of gastrointestinal bleeding. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, CYMBALTA should be stopped promptly, and linezolid or intravenous methylene blue can be administered.

The most commonly observed adverse reactions in CYMBALTA-treated patients (as defined above) were nausea, fatigue, constipation, dry mouth, insomnia, somnolence, and dizziness. Cases with serum sodium lower than 110 mmol/L have been reported and appeared to be reversible when CYMBALTA was discontinued. Do not open the capsule and sprinkle its contents on food or mix with liquids. CYMBALTA can be given without regard to meals. It's just good to be cautious, you've only got one liver. Is a good antidepressant but does cause some weight gain (15 pounds); however, I'd rather be a little over weight and happy than having horrible anxiety every day. Plasma TCA concentrations may need to be monitored and the dose of the TCA may need to be reduced if a TCA is co-administered with CYMBALTA. The risk of falling appears to be related to the degree of orthostatic decrease in blood pressure as well as other factors that may increase the underlying risk of falls. Not sure if I want to go through this again. Iodine doesn’t provide medical advice, diagnosis, treatment, or prescriptions.



Duloxetine - Wikipedia
Duloxetine, sold under the brand name Cymbalta among others, is a medication mostly used for major depressive disorder, generalized anxiety disorder, fibromyalgia and ... Duloxetine cymbalta generic available Cymbalta (duloxetine) dosing, indications, interactions ...Medscape - Generalized anxiety disorder, major depressive disorder, fibromyalgia-specific dosing for Cymbalta (duloxetine), frequency-based adverse effects ...

Let your doctor know immediately if you notice any of these things. Came off cold turkey side effects are terrible. If a dose of CYMBALTA is missed, take the missed dose as soon as it is remembered. Duloxetine comprises about 3% of the total radiolabeled material in the plasma, indicating that it undergoes extensive metabolism to numerous metabolites. CYMBALTA should be discontinued before initiating treatment with the MAOI [see If concomitant use of CYMBALTA with other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, amphetamines, and St.

Nevertheless, if a decision is made to increase the dose beyond 60 mg once daily, increase dose in increments of 30 mg once daily. Falls with serious consequences including bone fractures and hospitalizations have been reported [see syndrome has been reported with SNRIs and SSRIs, including CYMBALTA, alone but particularly with concomitant use of other serotonergic drugs (including triptans, of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Events for which there was a significant dose-dependent relationship in fixed-dose studies, excluding three MDD Also includes initial insomnia, middle insomnia, and early morning awakening. The population studied (N=476) was 7 to 17 years of age with 42. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate secretion (SIADH).

Consideration should be given to dose reduction or discontinuation of CYMBALTA in patients who experience symptomatic orthostatic hypotension, falls and/or syncope during CYMBALTA therapy. Serotonin syndrome symptoms may include mental status changes (e. Patients received 30-120 mg per day during placebo-controlled acute treatment studies. The risk of blood pressure decreases may be greater in patients taking concomitant medications that induce orthostatic hypotension (such as antihypertensives) or are potent CYP1A2 inhibitors [see ] and in patients taking CYMBALTA at doses above 60 mg daily. Reactions reported during the studies were not necessarily caused by the therapy, and the frequencies do not reflect investigator impression (assessment) of causality. The 20 and 60 mg capsules also contain iron oxide yellow. CYMBALTA has not been systematically evaluated in patients with a recent history of. Risk appears to be related to the presence of orthostatic decrease in blood pressure. Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure. For this reason, CYMBALTA should not be prescribed for patients with substantial alcohol use [see Given the primary CNS effects of CYMBALTA, it should be used with caution when it is taken in combination with or substituted for other centrally acting drugs, including those with a similar mechanism of action [see may occur as a result of treatment with SSRIs and SNRIs, including CYMBALTA.


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